Interpretability is a pressing issue for machine learning. Common approaches to interpretable machine learning constrain interactions between features of the input, rendering the effects of those features on a model's output comprehensible but at the expense of model complexity. We approach interpretability from a new angle: constrain the information about the features without restricting the complexity of the model. Borrowing from information theory, we use the Distributed Information Bottleneck to find optimal compressions of each feature that maximally preserve information about the output. The learned information allocation, by feature and by feature value, provides rich opportunities for interpretation, particularly in problems with many features and complex feature interactions. The central object of analysis is not a single trained model, but rather a spectrum of models serving as approximations that leverage variable amounts of information about the inputs. Information is allocated to features by their relevance to the output, thereby solving the problem of feature selection by constructing a learned continuum of feature inclusion-to-exclusion. The optimal compression of each feature -- at every stage of approximation -- allows fine-grained inspection of the distinctions among feature values that are most impactful for prediction. We develop a framework for extracting insight from the spectrum of approximate models and demonstrate its utility on a range of tabular datasets.

单图像姿势估计是许多视觉和机器人任务中的一个基本问题，并且现有的深度学习方法不会完全建模和处理来遭受：i）关于预测的不确定性，ii）具有多个（有时是无限）正确姿势的对称对象。为此，我们引入了一种在SO（3）上估算任意非参数分布的方法。我们的关键思想是通过神经网络隐含地表示分布，该神经网络估计给定输入图像和候选姿势的概率。网格采样或梯度上升可用于找到最有可能的姿势，但也可以评估任何姿势的概率，从而实现关于对称性和不确定性的推理。这是代表流形分布的最通用方法，为了展示丰富的表现力，我们介绍了一个具有挑战性的对称和几乎对称对象的数据集。我们不需要对姿势不确定性的监督 - 模型仅以一个示例训练单个姿势。但是，我们的隐式模型具有高度表达能力在3D姿势上处理复杂的分布，同时仍然在标准的非歧义环境上获得准确的姿势估计，从而在Pascal3d+和ModelNet10-SO-SO（3）基准方面实现了最先进的性能。

代表性学习形成最深入的学习应用的骨干，并且学习表示的值与其关于不同变异因素的信息内容密切相关。找到良好的表现取决于监督和学习算法的性质。我们提出了一种新颖的算法，该算法利用弱形的监督形式，其中数据根据各种变体的某些无效（常见）因子来划分到集合中，这些因素在每个集合的元素中不变。我们的主要识别是，通过寻求不同集合之间的对应，我们学习强烈的表示，排除了变异的非活动因素，并隔离了所有集合中变化的活动（不同）因素。由于重点关注有源因素，我们的方法可以利用设定监督和全文无监督数据的混合，甚至可以属于不同的域。我们通过将概括到类别水平和综合/真实域间隙的图像姿势信息隔离，解决综合对象姿势转移的具有挑战性问题，即使没有对任何内容的姿势注释也没有姿势注释。通过加强中间表示，该方法还可以提高监督设置的性能。

We present Muse, a text-to-image Transformer model that achieves state-of-the-art image generation performance while being significantly more efficient than diffusion or autoregressive models. Muse is trained on a masked modeling task in discrete token space: given the text embedding extracted from a pre-trained large language model (LLM), Muse is trained to predict randomly masked image tokens. Compared to pixel-space diffusion models, such as Imagen and DALL-E 2, Muse is significantly more efficient due to the use of discrete tokens and requiring fewer sampling iterations; compared to autoregressive models, such as Parti, Muse is more efficient due to the use of parallel decoding. The use of a pre-trained LLM enables fine-grained language understanding, translating to high-fidelity image generation and the understanding of visual concepts such as objects, their spatial relationships, pose, cardinality etc. Our 900M parameter model achieves a new SOTA on CC3M, with an FID score of 6.06. The Muse 3B parameter model achieves an FID of 7.88 on zero-shot COCO evaluation, along with a CLIP score of 0.32. Muse also directly enables a number of image editing applications without the need to fine-tune or invert the model: inpainting, outpainting, and mask-free editing. More results are available at https://muse-model.github.io

Autonomous robotic surgery has advanced significantly based on analysis of visual and temporal cues in surgical workflow, but relational cues from domain knowledge remain under investigation. Complex relations in surgical annotations can be divided into intra- and inter-relations, both valuable to autonomous systems to comprehend surgical workflows. Intra- and inter-relations describe the relevance of various categories within a particular annotation type and the relevance of different annotation types, respectively. This paper aims to systematically investigate the importance of relational cues in surgery. First, we contribute the RLLS12M dataset, a large-scale collection of robotic left lateral sectionectomy (RLLS), by curating 50 videos of 50 patients operated by 5 surgeons and annotating a hierarchical workflow, which consists of 3 inter- and 6 intra-relations, 6 steps, 15 tasks, and 38 activities represented as the triplet of 11 instruments, 8 actions, and 16 objects, totaling 2,113,510 video frames and 12,681,060 annotation entities. Correspondingly, we propose a multi-relation purification hybrid network (MURPHY), which aptly incorporates novel relation modules to augment the feature representation by purifying relational features using the intra- and inter-relations embodied in annotations. The intra-relation module leverages a R-GCN to implant visual features in different graph relations, which are aggregated using a targeted relation purification with affinity information measuring label consistency and feature similarity. The inter-relation module is motivated by attention mechanisms to regularize the influence of relational features based on the hierarchy of annotation types from the domain knowledge. Extensive experimental results on the curated RLLS dataset confirm the effectiveness of our approach, demonstrating that relations matter in surgical workflow analysis.

Research around AI for Science has seen significant success since the rise of deep learning models over the past decade, even with longstanding challenges such as protein structure prediction. However, this fast development inevitably made their flaws apparent -- especially in domains of reasoning where understanding the cause-effect relationship is important. One such domain is drug discovery, in which such understanding is required to make sense of data otherwise plagued by spurious correlations. Said spuriousness only becomes worse with the ongoing trend of ever-increasing amounts of data in the life sciences and thereby restricts researchers in their ability to understand disease biology and create better therapeutics. Therefore, to advance the science of drug discovery with AI it is becoming necessary to formulate the key problems in the language of causality, which allows the explication of modelling assumptions needed for identifying true cause-effect relationships. In this attention paper, we present causal drug discovery as the craft of creating models that ground the process of drug discovery in causal reasoning.

Recent work has reported that AI classifiers trained on audio recordings can accurately predict severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection status. Here, we undertake a large scale study of audio-based deep learning classifiers, as part of the UK governments pandemic response. We collect and analyse a dataset of audio recordings from 67,842 individuals with linked metadata, including reverse transcription polymerase chain reaction (PCR) test outcomes, of whom 23,514 tested positive for SARS CoV 2. Subjects were recruited via the UK governments National Health Service Test-and-Trace programme and the REal-time Assessment of Community Transmission (REACT) randomised surveillance survey. In an unadjusted analysis of our dataset AI classifiers predict SARS-CoV-2 infection status with high accuracy (Receiver Operating Characteristic Area Under the Curve (ROCAUC) 0.846 [0.838, 0.854]) consistent with the findings of previous studies. However, after matching on measured confounders, such as age, gender, and self reported symptoms, our classifiers performance is much weaker (ROC-AUC 0.619 [0.594, 0.644]). Upon quantifying the utility of audio based classifiers in practical settings, we find them to be outperformed by simple predictive scores based on user reported symptoms.

Since early in the coronavirus disease 2019 (COVID-19) pandemic, there has been interest in using artificial intelligence methods to predict COVID-19 infection status based on vocal audio signals, for example cough recordings. However, existing studies have limitations in terms of data collection and of the assessment of the performances of the proposed predictive models. This paper rigorously assesses state-of-the-art machine learning techniques used to predict COVID-19 infection status based on vocal audio signals, using a dataset collected by the UK Health Security Agency. This dataset includes acoustic recordings and extensive study participant meta-data. We provide guidelines on testing the performance of methods to classify COVID-19 infection status based on acoustic features and we discuss how these can be extended more generally to the development and assessment of predictive methods based on public health datasets.

The UK COVID-19 Vocal Audio Dataset is designed for the training and evaluation of machine learning models that classify SARS-CoV-2 infection status or associated respiratory symptoms using vocal audio. The UK Health Security Agency recruited voluntary participants through the national Test and Trace programme and the REACT-1 survey in England from March 2021 to March 2022, during dominant transmission of the Alpha and Delta SARS-CoV-2 variants and some Omicron variant sublineages. Audio recordings of volitional coughs, exhalations, and speech were collected in the 'Speak up to help beat coronavirus' digital survey alongside demographic, self-reported symptom and respiratory condition data, and linked to SARS-CoV-2 test results. The UK COVID-19 Vocal Audio Dataset represents the largest collection of SARS-CoV-2 PCR-referenced audio recordings to date. PCR results were linked to 70,794 of 72,999 participants and 24,155 of 25,776 positive cases. Respiratory symptoms were reported by 45.62% of participants. This dataset has additional potential uses for bioacoustics research, with 11.30% participants reporting asthma, and 27.20% with linked influenza PCR test results.

Mobile health (mHealth) technologies empower patients to adopt/maintain healthy behaviors in their daily lives, by providing interventions (e.g. push notifications) tailored to the user's needs. In these settings, without intervention, human decision making may be impaired (e.g. valuing near term pleasure over own long term goals). In this work, we formalize this relationship with a framework in which the user optimizes a (potentially impaired) Markov Decision Process (MDP) and the mHealth agent intervenes on the user's MDP parameters. We show that different types of impairments imply different types of optimal intervention. We also provide analytical and empirical explorations of these differences.